Co-trimoxazole, which was first sold in 1974, is an antibiotic used to treat a variety of bacterial infections such as urinary tract infections, travelers' diarrhea, respiratory tract infections, and cholera, among others. In addition, this drug may be used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS. As a matter of fact, Co-trimoxazole kills bacteria by blocking the making and use of folate by the microorganisms. Remember that you should take this medication with some food or drink so you wouldn’t feel sick (nausea) or have diarrhea. Although it is better to take Co-trimoxazole with food, you can still take it on an empty stomach. However, you’re going to have to drink plenty of fluid such as water, in case you choose to take it without food. As far as the side effects of this medication are concerned, they include nausea, vomiting, rash, and diarrhea. Bear in mind that the use of Co-trimoxazole during pregnancy is not recommended, even though this drug appears to be safe for use during breastfeeding as long as the baby is healthy.