Noctiva (Desmopressin nasal spray) is used to treat central cranial diabetes, which is a condition that causes the body to lose too much fluid and become dehydrated. It is also used to control frequent urination and increased thirst caused by certain types of brain injury or brain surgery. Before you use this medication, you need to tell your doctor if you have kidney disease or if you have ever had low sodium levels. Bear in mind that NOCTIVA is contraindicated in patients with hyponatremia or a history of hyponatremia. It is also worth noting that there are still no data with NOCTIVA use in pregnant women to determine whether there are any risks associated with this drug. As for the sides effects, they can include signs of an allergic reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat. So, if you experience any of these symptoms, you need to tell your doctor or get medical help right away.