Acetaminophen, diphenhydramine, and dextromethorphan is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, and sore throat caused by allergies, the common cold, or the flu. Acetaminophen, for instance, is a pain reliever and fever reducer. As for Diphenhydramine, it is an antihistamine that reduces the effects of the natural chemical histamine in the body. It is worth noting that histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Dextromethorphan, on the other hand, is a cough suppressant that affects the cough reflex in the brain, which in turn triggers coughing. Bear in mind that this combination medicine will not treat a cough that is caused by smoking, asthma, or emphysema. In rare cases, Acetaminophen may actually cause a severe skin reaction that can be fatal. This could occur even if you have taken the medication in the past and had no reaction. Therefore, you should stop taking it and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. Besides, if you have this type of reaction, you should never again take any medicine that contains acetaminophen. It is still, however, not known whether Acetaminophen, diphenhydramine, and dextromethorphan combination medicine will harm an unborn baby. In fact, it is not recommended that you use cough and cold medicine without a doctor's advice if you are pregnant. Also bear in mind that this medicine may pass into breast milk and may harm a nursing baby, not to mention that it may also slow breast-milk production.