Patented in 1969, Fenofibrate is a medication used along with a proper diet to help lower "bad" cholesterol and fats and raise "good" cholesterol (HDL) in the blood. It is worth noting that this medication works by increasing the natural substance (enzyme) that breaks down fats in the blood. Before you go ahead and use Fenofibrate, you need to tell your doctor if you have any of these health problems: Gallbladder disease, kidney disease, liver disease, or rise in liver enzymes. You also need to tell them if you are breast-feeding, because you should not breast-feed while you take this medicine. You may also need to avoid breast-feeding for some time after your last dose. In fact, using Fenofibrate during pregnancy is also not recommended. As for the side effects of using Fenofibrate, they include liver problems, breathing problems, abdominal pain, muscle problems, and nausea. In addition, this medication has other side effects that are rather serious such as toxic epidermal necrolysis, rhabdomyolysis, gallstones, blood clots, and pancreatitis. Remember that the recommended initial dose is one capsule taken daily during a main meal. And since it is less well absorbed from an empty stomach, Fenofibrate capsules should always be taken with food.