Approved for medical use in 1964, Polymyxin-b is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled. Technically speaking, Polymyxin B works by breaking down the cytoplasmic membrane which generally results in bacterial cell death. When it comes to the side effects of this antibiotic, they can include kidney problems, neurological problems, fever, itchiness, and rash – All of which occur when Polymyxin-b is given by injection. In addition, injecting the antibiotic into muscle may also result in significant pain. Other serious side effects may include fungal infections, anaphylaxis, and muscle weakness. It is worth noting that it is still unclear if using Polymyxin B during pregnancy is safe for the baby.