Patented in 1987, Rosiglitazone is an anti-diabetic drug that works as an insulin sensitizer. Plus, it is marketed as a stand-alone drug or for use in combination with metformin or with glimepiride. Despite Rosiglitazone's effectiveness at decreasing blood sugar in type 2 diabetes mellitus, its use decreased dramatically as studies showed apparent associations with increased risks of heart attacks and death. Some reviewers even recommended this drug be taken off the market, but an FDA panel disagreed, and it remains available in the United States. Bear in mind that Rosiglitazone tablets should be swallowed with a glass of water. Besides, they may be taken with or after a meal or on an empty stomach. It is worth noting that this medication should not be used during pregnancy, even though it is still not known if Rosiglitazone can harm your unborn baby. However, you and your doctor should talk about the best way to control your diabetes during pregnancy. In addition, you should not use this drug while breastfeeding, considering it is also not known if Rosiglitazone passes into breast milk.