Patented in 1965, Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue, in the cheek, by injection, as a skin patch, or as an implant. It is worth noting that Buprenorphine works by knocking other opioids in the brain off their receptors and binding tightly to the same receptors, so that other opioids cannot occupy them. Besides, Buprenorphine prevents withdrawal symptoms and reduces drug cravings. As for the side effects, they may include respiratory depression, sleepiness, adrenal insufficiency, QT prolongation, low blood pressure, allergic reactions, and opioid addiction. In fact, there is a risk of further seizures among those with a history of them. However, opioid withdrawal following stopping Buprenorphine is generally less severe than with other opioids. It is unclear, though, if using this opioid during pregnancy is safe, even though its use while breastfeeding is not recommended. Remember that you can take Buprenorphine on an empty stomach or after a meal.