Available under “Santyl”, Collagenase is a topical medication used to treat burns and to improve wound healing. Considering the fact that Collagenase may interact with other drugs, telling your doctor if you’re using any drugs at all before applying it is highly recommended. You should also tell them if you are pregnant or breastfeeding before using the medicine in question. Bear in mind that you should avoid putting Collagenase on healthy skin, and that you should only put it on the affected area. As for the side effects that must be reported to the doctor, they include itching, trouble breathing, hives, flu symptoms, and painful urination. Thankfully, though, these side effects are deemed rare. However, that does not mean they could not happen from time to time. So, make sure you call your doctor if you experience any of them.