dolutegravir rilpivirine

Dolutegravir-rilpivirine is a two-drug, single-tablet regimen that is used to help control HIV infection. This combination therapy helps to decrease the amount of HIV in your body so your immune system can work better. Eventually, this lowers your chance of getting HIV complications such as new infections and cancer, not to mention that it improves your quality of life. It is worth noting that both Dolutegravir and rilpivirine block the virus from growing and infecting more cells. When it comes to the adverse effects of Dolutegravir, they are rather uncommon and usually mild. Headaches, insomnia, and psychiatric symptoms have been reported, as have rash and hypersensitivity reaction. As for Rilpivirine, it is generally well tolerated, but adverse effects can include headache, insomnia, depression, rash, or elevated hepatic aminotransferase levels. Bear in mind that there are no recommendations for the use of the fixed-drug dolutegravir-rilpivirine in pregnancy. In fact, an FDA Safety Alert was posted in 2018 that warned of potential serious neural tube birth defects in infants born to mothers who received dolutegravir at the time of becoming pregnant or early in the first trimester.