“Drospirenone and estradiol” combination medicine is indicated for the treatment of menopause-related symptoms such as moderate to severe hot flashes. It is also used to treat low amounts of estrogen in women who still have a uterus, and to treat vaginal changes such as itching, dryness, and burning. Remember that you need to tell your doctor (before you use this combination) about your other health issues such as kidney/liver disease, blood clots, or if you’ve ever had a stroke/heart attack. You also need to avoid smoking during your treatment as it can raise you chance of heart disease. When it comes to the side effects, they include liver problems, allergic reaction, weakness on one side of your body, vision changes, breast pain, and memory problems. Bear in mind that you need to call your doctor immediately as soon as any of these side effects occurs. It is worth noting that “Drospirenone and estradiol” combination medicine is not recommended during pregnancy. So, you’ll need to take another medication if you are already pregnant, or use birth control if you aren’t. It is also worth noting that you can take this medication with or without food, although it would be better if you took it with food if it caused an upset stomach.