Clindamycin-tretinoin topical is a combination medicine indicated for the treatment of “severe nodular acne in adults and children who are at least 12 years old”. It is worth noting that Clindamycin is an antibiotic that basically fights bacteria in the body. As for Tretinoin, it lowers the amount of oil released by oil glands in the skin, not to mention that it helps our skin renew itself faster (especially since Tretinoin is basically a form of Vitamin A). According to drugs.com, Clindamycin-tretinoin combination medicine is not for everybody, because “you should not use this medication if you have ulcerative colitis, Crohn's disease, inflammation of your intestines, or if you have ever had severe diarrhea caused by antibiotic medicine.” Bear in mind that you need to tell your doctor beforehand if you are pregnant or breastfeeding, considering it is not known whether Clindamycin-tretinoin combination medicine can harm the unborn baby/ the nursing infant. When it comes to the common side effects, they include mild skin irritation/redness, and itching of the treated area. Remember that you should stop using the product in question immediately and call a doctor when you have bloody diarrhea, or severe redness of the treated area.