The combination of “Aspirin, sodium bicarbonate, and citric acid” is indicated for the relief of pain one feels as a result of heartburn, acid indigestion or upset stomach. Aspirin is basically used as a painkiller, whereas sodium bicarbonate is used as an antacid. As for citric acid, it helps prevent kidney stones. The combination treatment of “Aspirin, sodium bicarbonate, and citric acid” can also be used to reduce the risk of having a heart attack, stroke, or other issues that may occur when blood clots block a blood vessel. Bear in mind that any medicine containing Aspirin may cause Reye's syndrome in children with fever caused by the flu or the chickenpox. Therefore, you must not give this combination medicine to a child with fever without first consulting a doctor. It is still not clear, though, if using “Aspirin, sodium bicarbonate, and citric acid” during pregnancy will harm an unborn baby, considering there are no adequate studies in pregnant women using this combination. So, you should seek professional advice before using it. According to drugs.com, “the presence of other medical problems may affect the use of aspirin, sodium bicarbonate, and citric acid.” Therefore, informing your doctor of any other medical problems you may be having is highly recommended. Thankfully, the following side effects are rather rare among people who use the combination in question. However, they may still happen if you take too much medicine. These side effects include behavioral change, diarrhea, hallucinations, and bloody urine.